President Trump, in a burst of presidential action unmatched in modern U.S. history, has loosed a flurry of executive orders ...

地舒单抗地舒单抗在临床用于骨质疏松、骨巨细胞瘤、多发性骨髓瘤和实体肿瘤骨转移的治疗。这是目前唯一上市的RANKL抑制剂。它可以与RANK蛋白竞争性结合RANKL蛋白，从而抑制RANKL-RANK-OPG信号通路介导的破骨细胞分化与激活，降低破骨活动， ...

Receptor activator of nuclear factor-κB (RANK) is activated by its ligand, RANKL, an essential molecule for osteoclast development: in the absence of RANKL or RANK, osteoclast differentiation ...

No writing assistance was utilized in the production of this manuscript. RANKL expression is stimulated in osteoblasts and osteocytes by cytokines and hormones, and plays an important role in ...