RIPK1 – or receptor-interacting serine/threonine-protein kinase 1 – is thought to play a role in regulating the immune system, and has been a target for programmes both in inflammatory ...

Institute of Cancer Research UK has identified proteolysis targeting chimeras (PROTACs) comprising a Von Hippel-Lindau disease tumor suppressor (VHL) binding moiety coupled to a receptor-interacting ...

TAK1 is a key mediator of human inflammatory bowel diseases (IBD) through the NF-kB pathway. Here, the authors show that TAK1 phosphorylates TRADD, which cooperates with RIPK1 to intestinal ...

Mammalian hosts coordinate various cell death pathways as part of the immune defense system against pathogens including Mycobacterium tuberculosis ...

Mammalian hosts coordinate various cell death pathways as part of the immune defense system against pathogens including ...