What actually happens in the brain in cases of depression? Relatively unknown brain cells—"astrocytes"—are believed to play ...

New research shows astrocytes can remove Alzheimer’s-related amyloid-beta via autophagy, offering a promising new direction ...

A new cluster of reactive astrocytes emerged, with varied gene expression linked to neurogenic and reactive phenotypes.

(A) Increased expression of autophagy factors (LC3B, observed as blue dots) in astrocytes (GFAP) in the brain tissues of AD patients. (B) Increases in reactive astrocytes and autophagy gene ...

The group demonstrated a mechanism where the astrocytes in the brain uptake elevated levels of acetates, which turns them into hazardous reactive astrocytes. The researchers then developed a new ...

In an ALS study, growth factor FGF4 reduced the activity of star-shaped cells called astrocytes but did not stop motor ...

Mic.13 and tangles together triggered a reactive astrocyte state, Ast.10, characterized by expression of oxidative stress genes. Tangles and Ast.10 both contributed to cognitive decline. Ast.10 also ...

A key aspect of PD pathophysiology is neuroinflammation in the nigrostriatal pathway, including the presence of reactive astrocytes. This neuroinflammation has long been considered a downstream ...

Augmentation of acetate uptake, mediated by MCT1, facilitates Aβ-induced GABA release in reactive astrocyte. A. Blockade effect of MCT1 inhibitor on 14C-acetate uptake in primary cultured astrocytes.

To Jubao Duan of the University of Chicago, the authors provide compelling evidence. That tau dysregulation derails lipid droplets “provides novel mechanistic insight into how accumulation of human ...

C-reactive protein (CRP) levels have not been routinely used to diagnose thyroid disease, although many thyroid conditions involve inflammation. This study was intended to determine whether CRP ...