Opioid receptors are proteins in the nervous system ... Scientists first identified MORs due to their high affinity for morphine, and KORs due to their sensitivity for ketocyclazocine.

The point about "differential affinity and selectivity" is important, because different opioids bind more strongly or weakly to each receptor. This means that the degree to which each receptor is ...

NbE (red) binds the specific receptor responsible for opioid action (blue) and blocks off other small molecules (white/yellow/red). Opioid drugs are highly effective at relieving pain but come ...

Researchers have discovered a molecule, called nanobody NbE, which binds tightly and durably to the cell receptors that usually bind to opioids, thereby blocking the drugs' activity. Moreover ...

Though naloxone can bind to every kind of opioid receptor, it has a particular affinity for mu opioid receptors. Mu receptors can be bound by drugs like morphine, fentanyl, and heroin. Their ...

Scientists from the University of Geneva developed a nanobody, NbE, that binds tightly to opioid receptors, blocking their activity. This could mitigate the severe side effects of opioids and lead to ...

Prescription opioids are primarily used for pain relief. They work by attaching to opioid receptors in your brain cells to release signals that block your perception of pain and boost your ...

Neumora's lead asset, Navacaprant, shows weak efficacy in phase 2 trial. Read why we are not optimistic about NMRA's ...

The principal action of therapeutic value of buprenorphine is analgesia and is thought to be due to buprenorphine binding with high affinity to opioid receptors on neurons in the brain and spinal ...