Typically, TriAx antibodies target tumor-associated antigens and engage T cell receptors to redirect T cell cytotoxicity. These heterodimeric antibodies are designed primarily for the generation ...
In some instances of rhabdomyosarcoma, a rare cancer arising from muscle cells stalled in their journey toward their final non-dividing state, mutations to MyoD’s DNA-binding region redirect the ...
In doing so, the bispecifics redirect T cells of any specificity to target cells. ImmTAX molecules have inherent advantages over other modalities. The molecules recognize peptides derived from ...