Scientists use the term "stalled forks" for areas of replication forks where DNA polymerization is halted. Stalled forks activate ATR, which in turn phospohorylates its downstream target ...
The RF is a multiprotein complex with helicase and DNA synthesis activities. It is called a fork because the structure resembles a two-pronged fork. The helicase activities unwind DNA in front of ...
In eukaryotes, DNA replication initiates at many replication origins that are distributed along the length of each chromosome arm. At each origin, two replication forks are established that travel in ...
Dr. Tsubouchi concludes, "We propose that slow replication forks are not the manifestation of replication impediments but rather an integral feature of DNA replication in ES cells.
Research in my laboratory centers on: (i) the events that occur when the replisome (the multi-component enzyme machine that replicates chromosomal DNA) encounters blockages to replication fork ...
A new study has uncovered a previously unknown role for the enzyme EXD2, identifying it as a potential drug target for cancer therapy. Researchers showed that by protecting replication forks – the ...