In eukaryotes, DNA replication initiates at many replication origins that are distributed along the length of each chromosome arm. At each origin, two replication forks are established that travel in ...
Dr. Tsubouchi concludes, "We propose that slow replication forks are not the manifestation of replication impediments but rather an integral feature of DNA replication in ES cells.
Scientists use the term "stalled forks" for areas of replication forks where DNA polymerization is halted. Stalled forks activate ATR, which in turn phospohorylates its downstream target ...
The RF is a multiprotein complex with helicase and DNA synthesis activities. It is called a fork because the structure resembles a two-pronged fork. The helicase activities unwind DNA in front of ...