Scientists use the term "stalled forks" for areas of replication forks where DNA polymerization is halted. Stalled forks activate ATR, which in turn phospohorylates its downstream target ...
The replication fork is more than just a means for DNA duplication. It is connected to a checkpoint system that keeps the genome intact and prevents cancer. Aa Aa Aa Eukaryotic genomes are ...
Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...
Research in my laboratory centers on: (i) the events that occur when the replisome (the multi-component enzyme machine that replicates chromosomal DNA) encounters blockages to replication fork ...