In this study, our results uncover the function and mechanism of CHMP5 in the regulation of cell senescence and bone formation in osteogenic cells. Deletion of Chmp5 causes endolysosomal dysfunction ...

Reactive oxygen species (ROS) from mitochondria are key drivers of genetic chaos in cancer by causing the ... The findings identify key proteins in this destructive process – p62 and CHMP7 – revealing ...