综合上述研究结果，研究人员得出结论：酒精摄入会增加食管鳞癌患者外周循环中革兰氏阴性菌的丰度，基于肿瘤细胞中 TNF 通路的上调，酒精和 LPS 协同促进食管鳞癌细胞的增殖，而 LPS 促进正常鳞状细胞的死亡，最终加速食管鳞癌的发展。这一研究成果揭示了一种全新的食管鳞癌致病机制，即酒精诱导的外周循环微生物失调和 LPS ...

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