The zinc-dependent catalytic domain of the seven BoNT serotypes specifically cleaves one of three different SNARE proteins essential for synaptic vesicle fusion: synaptobrevin, syntaxin ...

"I work on a specific protein called SNAP-25," says Bhasne. "Without SNAP-25, the SNARE complex, which is responsible for guiding the synaptic vesicle to the right docking points on the ...

Our group focuses on two assembly pathways: adaptor protein assembly during vesicle budding and SNARE complex assembly during vesicle fusion. We aim to use findings from these two model pathways to ...

Researchers describe, for the first time, the full molecular cascade that comprises acrosomal exocytosis, an essential step in fertilization, in this week's PLoS Biology. "Exocytosis has been analyzed ...