Imaging the molecules in a dividing cell's "spindle," a protein structure that extends from one side of the cell to the other ...

Spindle fibers form a protein structure that divides the genetic material in a cell. The spindle is necessary to equally divide the chromosomes in a parental cell into two daughter cells during ...

In eukaryotes, segregation of duplicated chromosomes is performed by the mitotic spindle, a cellular machine composed of microtubules and their associated proteins. Spindles are built from ...

The chromosomal passenger complex (CPC) is involved in the proper orchestration of both mitosis and meiosis. The CPC comprises Aurora-B protein kinase, the inner centromere protein (INCENP ...

Motor motion on cytoskeletal filaments is particularly important for biological length regulation, because numerous proteins targeted to microtubule ends modify their dynamics and can dramatically ...

The hybrid microscope can be useful for studying proteins, as they change their 3D orientation in response to their ...

The microscope's ability to record 3D protein orientation changes is crucial for understanding how proteins interact with ...

The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...

Because the core centromere function of connecting to the spindle is highly conserved across eukaryotes, we expect that centromere components would also be conserved. Contrary to this expectation, ...

Two heads are better than one, as the saying goes, and sometimes two instruments, ingeniously recombined, can accomplish ...

A hybrid microscope allows scientists to simultaneously image the full 3D orientation and position of an ensemble of molecules, such as labeled proteins inside cells. The microscope combines polarized ...

When two instruments are cleverly recombined, they can sometimes achieve things that neither instrument could have done alone ...