Lessons learned from these two model organisms also apply to cells that divide asymmetrically in other metazoans, such as self-renewing stem cells in mammals. Asymmetric cell division is crucial ...
If cells are removed from the embryo they will differentiate into any cell type. These are called embryonic stem cells. Some stem cells remain in the bodies of adults as adult stem cells.
for example bone marrow transplants, corneal transplants, and skin grafts for burns. Stem cells have also been used as model cells to study how diseases develop or for drug testing.
We discovered that interferon gamma (IFNγ) promotes hematopoietic stem cell (HSC) division and myeloid differentiation in a mouse model of Mycobacterium avium infection (Nature 2010). Furthermore, ...
Resolving how cell of origin affects pathways that govern progression of precancerous lesions will ultimately allow us to develop methods to detect PDAC early, which is arguably the most important ...