If cells are removed from the embryo they will differentiate into any cell type. These are called embryonic stem cells. Some stem cells remain in the bodies of adults as adult stem cells.
Alternatives to primary cells include animal models, which may not effectively recapitulate the disease phenotype, or myocytes derived from human induced pluripotent stem cells (iPSCs).
Mitosis is a type of cell division which ensures that, when a cell divides, each new cell produced has the same genetic information. Each human body cell contains 46 chromosomes. These can be ...
We discovered that interferon gamma (IFNγ) promotes hematopoietic stem cell (HSC) division and myeloid differentiation in a mouse model of Mycobacterium avium infection (Nature 2010). Furthermore, ...
Its development is tightly controlled by genetic and epigenetic programs. Stem cell-based embryo models, such as blastoids, serve as models of the blastocyst and are invaluable tools for studying ...
Resolving how cell of origin affects pathways that govern progression of precancerous lesions will ultimately allow us to develop methods to detect PDAC early, which is arguably the most important ...
The goal of the Stem Cell program is to conduct rigorous scientific studies to enhance our knowledge of normal and altered stem cell development and to advance treatments and improve outcomes for ...