Deep brain stimulation (DBS) of the subthalamic nucleus has been shown to improve motor symptoms associated with Parkinson disease (PD), but the mechanism of this action is unclear. Previous ...

This included the subthalamic nucleus, "the region where electrodes typically get implanted to manage Parkinson's disease," ...

By calming the overactive neurons in the subthalamic nucleus, the researchers alleviated the characteristic motor disorders. According to the study published in Science Advances, the absence of side ...

AAV-GAD works by delivering the glutamic acid decarboxylase (GAD) enzyme to the subthalamic nucleus in the brain. GAD catalyses the conversion of glutamic acid into the amino acid gamma ...

The paper provides solid evidence that cortical and STN beta oscillations are sensitive to movement context and may play a role in the coordination of movement redirection. The role of beta band ...