Tumor suppressor genes make proteins that regulate the growth of cells, and they play an important role in preventing the development of cancer cells. When tumor suppressor genes are altered or ...
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Tumour-suppressor proteins act to alleviate the potential for cancer and tumour formation by modulating cell growth either through negative regulation of the cell cycle or by promoting apoptosis.
These mechanisms, including those involving the tumor suppressor protein p53, are widely studied due to their critical role in disease. Through studies of proteins that regulate p53, scientists at St.
It causes mutations in the p53 tumor-suppressor gene as well as ras mutations, which are involved in the majority of human cancers. Aflatoxin has been shown to contaminate tobacco products.