Excitatory synapses are located in confined chemical spaces called the dendritic spines. These are atypical femtoliter-order microdomains where the behavior of even single molecules may have ...

A tiny brain for immense discoveries. The fruit fly, this simple vinegar fly, holds within it the secrets of neural connections. Could understanding its brain pave the way for insights into human ...

An electrical impulse cannot directly cross the gap so a different mechanism has to be used. Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent ...

The post-synaptic side of the synapse is now recognized as a site ... which focuses on the cell biology of a number of ligand- and voltage-gated ion channels involved in post-synaptic ...

"Next, we are studying how to dynamically adapt these CAR T cells at the synapse level to make them more effective." "Tumors are very sophisticated. We need to adapt our tools to the biology of ...

Enter SynPull, a new synaptosome imaging method developed by David Klenerman, John Danial, and colleagues at the University of Cambridge, England. SynPull combines single-molecule pull-down of ...

Last semester, Sarah Trafton (senior, graphic design and illustration) was one of The Penn’s artist features but this semester we are featuring her again for a special reason.

However, a series of weak stimuli can combine, increasing the amount of neurotransmitter that is released. This results in enough neurotransmitter being diffused across the synaptic cleft to ...