synaptic strengthening and learning the authors used a single-whisker experience (SWE) protocol in which all but one of a mouse's whiskers were removed, resulting in the potentiation of synapses ...

Emerging evidence indicates that activity-dependent insertion and retrieval of NMDARs to and from synaptic sites mediates some forms of long-term potentiation (LTP) and long-term depression (LTD ...

In the 1970s, scientists discovered long-term potentiation (LTP), which detailed ... PKMzeta then attaches to the ...

“The persistent synaptic tagging mechanism for the first ... How can short-lived molecules selectively maintain the ...

To address this, researchers from University of Tsukuba focused on synaptic connections between neurons. They developed a novel molecular tool, SYNCit-K, which enhances synaptic strength ...

When Aβ aggregates stoke synaptic fires, tau tangles put them out. This phenomenon, demonstrated in animal models, now gains support in a human study, published September 18 in Nature Neuroscience.

We will then discuss the mechanisms of short- and long-term synaptic plasticity including the cellular and molecular mechanisms underlying long-term potentiation (LTP) and long-term depression (LTD).

[PubMed] [Content] Patenaude C, Chapman CA, Bertrand S, Congar P, Lacaille JC (2003) GABAB receptor- and metabotropic glutamate receptor-dependent cooperative long-term potentiation of rat hippocampal ...

The selective synaptic connections of photoreceptors with their corresponding downstream ON-bipolar neurons is essential for vision and dysfunction of photoreceptor synapses causes retinal diseases ...

This study presents an important finding on the involvement of a Caspase 3-dependent pathway in the elimination of synapses for retinogeniculate circuit refinement and eye-specific territory ...

Dysfunction of synaptic plastic processes is believed to be involved in various psychiatric and neurological disorders, including epilepsy and ischaemic brain injury. We are particularly interested in ...