Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...
The selection of this first target is a key step for the partnership between Medigene and WuXi Biologics, which aims to advance multiple TCR-TCEs over the next three years. The collaboration seeks to ...
Inflammatory processes are the body’s defence against local damage and disease. Inflammation involves the influx into organs of immune cells (white blood cells) from the blood. These cells deal with ...
During this process, the CD28-mediated co-stimulatory signal plays a central role. Multiple studies have now demonstrated that 4-1BBL can independently provide co-stimulatory signals to induce T cell ...
Despite its successes, CAR T-cell therapy faces challenges as treatment for solid tumors," said Joaquín Arribas. Tumors driven by HER2 overexpression In normal amounts, HER2 plays a crucial role in ...