Cancer cells impair monocyte-mediated T-cell activation by disrupting inflammatory pathways in the tumor microenvironment.
Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...
Shares of Glenmark Pharma Ltd. gained up to 4% on Tuesday, December 10, following first clinical data from the Phase 1 studi ...
The selection of this first target is a key step for the partnership between Medigene and WuXi Biologics, which aims to advance multiple TCR-TCEs over the next three years. The collaboration seeks to ...
Chemotherapy drugs can kill cancer cells by halting DNA replication, but a glucose-depleted environment can help cancer cells ...
In a recent article, researchers explored how calcium carbonate nanoparticles enhance T cell activation through calcium ...
During this process, the CD28-mediated co-stimulatory signal plays a central role. Multiple studies have now demonstrated that 4-1BBL can independently provide co-stimulatory signals to induce T cell ...
By inferring proliferation rates from single-cell genomics, SPRINTER enhances understanding of tumor evolution and identifies ...