Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...
The selection of this first target is a key step for the partnership between Medigene and WuXi Biologics, which aims to advance multiple TCR-TCEs over the next three years. The collaboration seeks to ...
During this process, the CD28-mediated co-stimulatory signal plays a central role. Multiple studies have now demonstrated that 4-1BBL can independently provide co-stimulatory signals to induce T cell ...