A significant body of data implicates the type I interferon (IFN) pathway in the pathogenesis of autoimmune rheumatic diseases. In these disorders, a self-reinforcing cycle of IFN production can ...

当RNA病毒感染时，信号转接器MAVS会在线粒体外膜上形成功能性的聚集体，作为连接病毒与下游抗病毒天然免疫反应的中心枢纽。目前已有多种调节MAVS激活的机制，但控制MAVS聚集的检查点尚未被发现。

Acquired resistance to PD-L1 inhibition can rewire the interferon-regulated secretory machinery in tumor cells, altering the ...

On the 50th anniversary of the discovery of interferon (IFN), we offer a perspective from more than 100,000 published papers, highlighting initial pivotal discoveries and more recent findings of ...

The following is a summary of “Type I interferon biomarker in idiopathic inflammatory myopathies: associations of Siglec-1 ...

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers, with a survival rate of just 11%. A primary culprit ...

Moreover, increased type I interferon signaling has been identified as a contributing factor to this dysfunction. Rheumatoid ...

Blood dendritic cell antigen 2 (BDCA2) is expressed in plasmacytoid dendritic cells. These cells’ overproduction of type I interferon is closely linked to the pathogenesis of systemic lupus ...

AstraZeneca understands the impact that autoimmune disease has on people’s quality of life. That’s why we’re working on trials such as JASMINE, to hopefully find a new treatment that could improve the ...