A significant body of data implicates the type I interferon (IFN) pathway in the pathogenesis of autoimmune rheumatic diseases. In these disorders, a self-reinforcing cycle of IFN production can ...
Cholesterol restriction-mediated SREBP1 activation induces noncanonical type I IFNs, including IFN-ω and minor IFN-α subsets, ...
The following is a summary of “Type I interferon biomarker in idiopathic inflammatory myopathies: associations of Siglec-1 ...
The Brighterside of News on MSN7d
Breakthrough immunotherapy drug revolutionizes pancreatic cancer treatmentPancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers, with a survival rate of just 11%. A primary culprit ...
3monon MSN
Moreover, increased type I interferon signaling has been identified as a contributing factor to this dysfunction. Rheumatoid ...
News Medical on MSN9d
Cancer cells block T-cell activation, but new therapies restore immune defensesCancer cells impair monocyte-mediated T-cell activation by disrupting inflammatory pathways in the tumor microenvironment.
AstraZeneca understands the impact that autoimmune disease has on people’s quality of life. That’s why we’re working on trials such as JASMINE, to hopefully find a new treatment that could improve the ...
Blood dendritic cell antigen 2 (BDCA2) is expressed in plasmacytoid dendritic cells. These cells’ overproduction of type I interferon is closely linked to the pathogenesis of systemic lupus ...
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