A knockout mouse is a laboratory mouse in which one or more genes have been turned off or "knocked out." To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene ...

The Knockout Mouse Phenotyping Program (KOMP2) sites at Baylor College of Medicine, Jackson Laboratory, and University of California, Davis, are collaborating with the International Mouse Phenotyping ...

However, because so many mouse genes are similar to human genes, geneticists can generate knockout mice in which the mouse counterpart of a human gene of interest is deleted or disrupted.