Using three different mutagenesis strategies coupled with a cell-surface binding assay, the authors identified a number of residues in the Frizzled 8 CRD that, when mutated, disrupt Wnt binding ...

Many cases of FEVR are linked to loss-of-funtion mutations in the Wnt receptor FZ4 (Frizzled 4). Loss-of-function mutations in WNT3 cause tetra-amelia, the loss of all four limbs. Acute renal ...

2006;3(5):267-274. The WNT signaling pathway. (A) In the absence of WNT binding to frizzled, dishevelled remains unactivated and β-catenin is targeted for degradation via the adenomatous ...