(A) Ran shuttles across the NE, with about 95% in the nucleus and 5% in the cytoplasm. A high concentration of RanGTP in the nucleus is maintained by RCC1, which catalyzes the formation of RanGTP.

The study offers an alternative approach to investigating the dynamics of protein compartmentalization, which may also be applicable to other biological systems. "The fundamental role played by ...

Although the NE is often depicted as a static barrier, new research has identified conditions where nuclear envelope rupturing causes a loss of compartmentalization. Nuclear envelope ruptures are ...