EurekAlert!1d
Researchers identify new p53 targets to combat cancer growth
A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled “Robust p53 phenotypes and ...
News Medical on MSN1d
Study finds key p53 targets for future cancer treatment
A new research paper was published in , Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells." ...
Nature23d
Inhibition of telomerase limits the growth of human cancer cells
To determine whether disruption of hTERT catalytic function would limit the growth of normal and malignant cells, we created a catalytically inactive, dominant negative form of hTERT. We expressed ...
Nature22d
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
Figure 1: Expression of pRb and p16 as a function of cell density. Figure 3: hTERT clones undergo normal growth arrest in response to PALA and γ-irradiation. Figure 4: hTERT clones arrest ...