While responses to inflammation may be necessary to maintain normal and emergency hematopoiesis, it may be deleterious over the long term, with prolonged inflammation leading to stem cell exhaustion ...

Normal hematopoiesis and immunity are best described by chaos, with myriad clones evolving and differentiating according to a stochastic model, a characteristic that endows this system with its ...

Improving human hematopoiesis in mice The present immunodeficient mouse models allow robust human lymphopoiesis from engrafted HSCs but generate few human myeloid cells and essentially no human ...