No writing assistance was utilized in the production of this manuscript. Lipid metabolism in homozygous familial hypercholesterolemia (HoFH) is abnormal owing to lack of functional LDL receptors ...

No writing assistance was utilized in the production of this manuscript. Homozygous familial hypercholesterolemia is a rare but significant cause of early-onset coronary heart disease. Early ...

In the equation, p 2 represents the frequency of the homozygous genotype AA, q 2 represents the frequency of the homozygous genotype aa, and 2pq represents the frequency of the heterozygous ...

Consequently, a test cross can help determine whether a dominant phenotype is homozygous or heterozygous for a specific allele. Diploid organisms, like humans, have two alleles at each genetic ...

Blood tests from children hospitalized with malaria found that nearly all were homozygous for the wild type of sickle cell allele. The few sickle cell carriers among them had the mildest cases of ...

Individuals A and B both have brown eyes, even though A is heterozygous and B is homozygous (dominant). Only people with a homozygous recessive genotype can have blue eyes as shown by individual C.

The study, published in Nature Medicine, also concludes that those individuals homozygous for APOE4 also develop the disease earlier than those with other variants of the APOE gene. These findings ...