2022年1月， 深圳市第二人民医院 (深圳大学第一附属医院) 在Mediators of Inflammation（IF4.3997 / 3区）上在线发表了一篇论文。在 发表3年后 ，因 图片组内重复 在pubpeer上被读者质疑。

Hyperpathia, hyperalgesia, and allodynia are three manifestations of central sensitization, a condition in which a higher than necessary degree of activity is triggered in the central nervous system.

Some of the central molecular mechanisms that lead to hyperalgesia and allodynia after peripheral tissue injury involve the spinal dorsal horn transient receptor potential vanilloid 1 (TRPV1).

As demonstrated in a novel mouse model, the mouse version of the drug (mIL-1 Trap) both prevented and relieved ankle joint synovitis and hyperalgesia induced by monosodium urate (MSU) crystals.