In a phase 1 trial, Sebetralstat was shown to be able to suppress plasma kallikrein activity nearly completely. A single 600 mg dose of Sebetralstat produced a 98% inhibition of plasma kallikrein ...
One capsule of Orladeyo per day works to prevent HAE attacks by decreasing the activity of plasma kallikrein. Orladeyo (berotralstat) is a plasma kallikrein inhibitor indicated for prophylaxis to ...