近日,华中科技大学武汉光电国家研究中心张智红教授团队在《表型组学(英文)(Phenomics)在线发表了题为“Modulating and Imaging Macrophage Reprogramming for Cancer ...
引言CAR-T(嵌合抗原受体T细胞)疗法在血液系统恶性肿瘤的治疗中取得了突破性进展。然而,由于实体瘤的肿瘤微环境(TME)高度免疫抑制、肿瘤抗原表达的异质性及T细胞渗透能力受限,CAR-T在实体瘤治疗中面临显著挑战。为克服这些问题,2月7日Nature Medicine的研究报道“CAR-macrophage therapy for HER2-overexpressing ...
Solid tumors are difficult to treat due to their heterogeneity and limited blood supply, which restrict the effective ...
Richard Staines spoke with Soren Bregenholt, the new CEO of Macrophage Pharma, about the company’s strategy encompassing both immune oncology and inflammatory diseases. In healthy tissues ...
Joint injury induces rapid and sustained diversification of resident and infiltrating synovial macrophage phenotypes, underpinning osteoarthritis-associated synovitis.
Inflammatory processes are the body’s defence against local damage and disease. Inflammation involves the influx into organs of immune cells (white blood cells) from the blood. These cells deal with ...
Inflammasomes are more active in the morning than the rest of the day. Macrophage activity, which regulates inflammation, is influenced by the biologic clock in the body. A team led by Annie ...