It acts as a tumor suppressor in many cancers but is oncogenic in certain tumors. We observed upregulation of RUNX3 mRNA and protein expression in nasal-type extranodal natural killer (NK)/T-cell ...

A recent study conducted by the Guangzhou Institutes of Biomedicine and Health (GIBH) of the Chinese Academy of Sciences (CAS ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.

Previously we found that activation of ERK output is dependent upon the mechanisms by which oncogenic mutants evade ERK-dependent feedback regulation. The loss of feedback regulation not only drives ...