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体外合成circRNA的Ⅰ型内含子序列、结构及自我剪接机制
Ⅰ型内含子是含量最为丰富的拥有自剪接活性的内含子,数量已经超过 20000 个,广泛分布于自然界中。 从细菌、真菌、原生生物及植物,到细胞核、线粒体及叶绿体,再到 mRNA、tRNA 及 rRNA 基因,你都可以发现它们的存在。
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