A certain synonymous codon can be optimal and efficient in one species and nonoptimal in another; this is called codon optimality. A new, less error-prone approach to sequencing Sars-CoV-2 genomes has ...

Synonymous mutations can also influence the speed of translation because the precise codon used determines how quickly it’s translated by ribosomes. For instance, one 2016 study reported that a ...

BIOPHYSICAL JOURNAL 114. (2018): 1009-1017. Print. * G.A., Babbitt, et al. "Triplet codon organization optimizes the impact of synonymous mutation on nucleic acid molecular dynamics." JOURNAL OF ...

was recoded with 631 synonymous mutations to give a codon pair bias ∼4.5-fold lower than that of wild-type poliovirus. The attenuated virus was further manipulated by recombining segments of ...