Neuropsychiatric disorders are becoming increasingly prevalent. Given their complex and multifactorial pathogenesis, there is ...

This study identifies 47,350 enhancers active in human neurons during differentiation and links some to genes involved in ...

Aging reshapes breast tissue, boosting cancer risk via epigenetic and immune shifts. Key insights for clinical practice.

The researchers then evaluated the similarities between the TC and LE regions from the 12 patient tissue sections in terms of their transcriptional profiles. They found that gene expression was highly ...

Daewoong Pharmaceutical Co. Ltd. has described transcriptional coactivator YAP1/transcriptional enhancer factor (TEAD) interaction inhibitors reported to be useful for the treatment of cancer.

Neuropsychiatric disorders are becoming increasingly prevalent. Given their complex and multifactorial pathogenesis, there is an urgent need for ...

Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo.I suggest that ∼ 90% of Pol II initiation events in ...

We study how the transcriptional networks are rewired in cancer cells, and how this rewiring could be exploited as cancer therapy. The major disease model of interest is prostate cancer, and ...

A comprehensive analysis has identified novel enhancers associated with neuronal development and disease.

The researchers used LUHMES neuronal precursor cells, which can differentiate into functional neurons with a high transcriptional similarity to human brain-derived neurons. They employed Cap ...