One of the conditions that could benefit from transcriptional therapy is a genetic disorder called Friedreich’s ataxia. It affects one in 40,000 people, most commonly those of European descent.

Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo. I suggest that ∼90% of Pol II initiation events in ...

研究人员首次发现，人类细胞自带一套精密的"应急修复系统"，当检测到关键基因故障时，会自动激活"替补基因"展开修复。更令人振奋的是，这项机制可被人工干预精确调控，为DMD乃至6000多种单基因遗传病带来 ...

Neuropsychiatric disorders are becoming increasingly prevalent. Given their complex and multifactorial pathogenesis, there is ...

The researchers used LUHMES neuronal precursor cells, which can differentiate into functional neurons with a high transcriptional similarity to human brain-derived neurons. They employed Cap ...

Daewoong Pharmaceutical Co. Ltd. has described transcriptional coactivator YAP1/transcriptional enhancer factor (TEAD) interaction inhibitors reported to be useful for the treatment of cancer.

A comprehensive analysis has identified novel enhancers associated with neuronal development and disease.

The researchers then evaluated the similarities between the TC and LE regions from the 12 patient tissue sections in terms of their transcriptional profiles. They found that gene expression was highly ...

We study how the transcriptional networks are rewired in cancer cells, and how this rewiring could be exploited as cancer therapy. The major disease model of interest is prostate cancer, and ...

Neuropsychiatric disorders are becoming increasingly prevalent. Given their complex and multifactorial pathogenesis, there is an urgent need for ...

Aging reshapes breast tissue, boosting cancer risk via epigenetic and immune shifts. Key insights for clinical practice.