CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

2020年，詹妮弗·杜德纳（Jennifer A. Doudna）教授与埃马纽埃尔·夏彭蒂耶（Emmanuelle Charpentier）共同荣获诺贝尔化学奖，以表彰她们共同开发了基因组编辑方法CRISPR的卓越贡献。 受Frontiers for Young Minds邀请，杜德纳撰文解释了CRISPR的工作原理以及她与合作者是如何发现这一机制的。杜德纳说， ...

The CRISPR-Cas9 system offers groundbreaking genome editing capabilities, yet off-target cleavage raises concerns about ...

No doubt 2025 will usher in many more advances in CRISPR therapies, thanks to the FDA’s new Platform Technology Designation ...

Mammoth Biosciences researchers have developed NanoCas, an ultracompact CRISPR nuclease, demonstrating its ability to perform ...

Researchers using CRISPR-Cas9 gene editing tools have discovered that while this technology can enhance ... or nicks, in the DNA. Base editing is a genome editing system that uses an impaired Cas ...

When the gene editing tool CRISPR-Cas9 rocketed to fame more than a decade ago, it transformed biotechnology. Faster, cheaper, and safer than previous methods, the tool helped scientists gain insight ...

By Balambal Suryanarayanan CRISPR-Cas9 is a repurposed gene editing tool that allows scientists to cut, replace, and insert pieces of DNA in precise regions along the strand. Courtesy of NIH Image ...

Researchers find a master epigenetic switch that activates silenced genes to compensate for their missing counterparts in a ...

SGE is mainly based on the versatile CRISPR-Cas9 genome editing system. CRISPR-Cas9 comprises a guide RNA (gRNA) that directs the Cas9 endonuclease enzyme to a specific DNA sequence. Cas9 then ...

A UCO team has applied the genome editing technique, which garnered a Nobel Prize in Chemistry in 2020, to unravel the ...