TCR-based T cells are MHC-dependent, meaning they are limited to treating patients with specific MHC types. They can recognize both intracellular and cell surface antigens by associating with MHC, ...

Containing mutations in the MHC α3 domain that ablate CD8 binding; can be used to quantitate and to sort CD8-independent T cells. Developing high-affinity soluble antibody molecules endowed with a TCR ...

T cells use the T cell antigen-receptor (TCR) to recognize their antigens, which are often in the form of peptides bound to major histocompatibility complex molecules (MHC), also called HLA (human ...

However, functional analysis and in vivo transfer of MHC multimer-stained cells is hampered by the persistence of T-cell receptor (TCR)–MHC interactions and subsequently induced signaling events.

在免疫学领域，CD8+T 细胞在抵抗病毒感染、癌症以及自身免疫疾病中扮演着至关重要的角色。因此，准确预测 T 细胞受体（TCR，T cell receptor）与主要组织相容性复合物（MHC，Major Histocompatibility ...

The composition of these aAPC allows free movement of the MHC–peptide complexes in the artificial membrane. We show here active clustering of TCR–MHC molecules at the immune synapse after ...

T cells are activated in a dual-signal process: the first signal binds the peptide-MHC complex on the surface of the APC to the T-cell receptor (TCR); the second signal involves the interaction of ...