Adeno-associated viruses (AAV) have emerged as the lead vector in clinical trials and form the basis for several approved gene therapies for human diseases, mainly owing to their ability to sustain ...

In addition, first-generation CRISPR systems (Cas9 and Cas12a) are too large for efficient in vivo delivery via a single adeno-associated viral (AAV) vector. Now, new preclinical research ...

Yet many more applications await. One of the most actively investigated gene transfer vehicles and emerging platforms is that of adeno-associated virus (AAV). Simply put, AAV consists of a protein ...

Tee Higgins could be due for a massive contract this offseason. Per ESPN's Jeremy Fowler, the Cincinnati Bengals wide receiver's market is expected to be around $30 million per year. "The over ...

通过对正常肝脏和脂肪肝肝脏的比较，研究人员发现，脂肪肝对AAV载体的转导效率和特异性有显著影响，不同AAV载体的转导表现也因病理状态的不同 ...

This report describes the impact of glycosylation on the pharmacokinetics, pharmacodynamics, therapeutic activity, and production (biomanufacturing) of therapeutic proteins using several examples that ...

Phylogeny for birds Under this system, organisms are grouped into "clades," which are distinct branches on the phylogenetic tree that include all the descendants of a most recent shared ancestor ...