Mammoth Biosciences researchers have developed NanoCas, an ultracompact CRISPR nuclease, demonstrating its ability to perform ...

Adeno-associated viruses (AAV) have emerged as the lead vector ... i.e., the recombinant genome consisting of the transgene expression cassette flanked by the ITRs, offers multiple opportunities for ...

In addition, first-generation CRISPR systems (Cas9 and Cas12a) are too large for efficient in vivo delivery via a single adeno-associated viral (AAV) vector. Now, new preclinical research ...

Simply put, AAV consists of a protein shell (capsid) encasing a small single-stranded DNA genome. For recombinant versions (rAAV), scientists replace the viral genome with the desired therapeutic ...

Adeno-associated virus 2 (AAV)-based vectors have gained attention as a potentially useful alternative to the more commonly used retroviral and adenoviral vectors for human gene therapy.

In addition, we describe the relationship between 3D genome structure and the differentiation and maturation of immune cells and address how changes in chromosome folding contribute to autoimmune ...

Precision BioSciences, Inc. (Nasdaq: DTIL), a clinical stage gene editing company utilizing its novel proprietary ARCUS® ...

Physicists model chromosome folding, reveal how loops affect spatial organization of the genome Nov 22, 2023 Russian scientists discover a new function of the nucleus lamina proteins ...