Adenoviral vectors will transduce a wide range of target cells resulting in high-level gene expression. They are non-integrating vectors so expression in dividing cells is progressively lost. First ...

Ad5 vectors are the most commonly used adenovirus vector. Ad5 vectors transduce a wide range of cell types. They utilize the Coxsackie-Adenovirus Receptor (CAR) to enter cells. Transduction efficiency ...

Cerepro—which consists of the herpes simplex virus gene for thymidine kinase (TK) encased in an adenoviral vector in which the E1 and part of the E3 regions have been deleted to prevent ...

At the height of the COVID-19 pandemic in 2021, VITT emerged as a new disease following adenovirus vector-based vaccines—notably the Oxford-AstraZeneca vaccine. VITT was found to be caused by an ...

The most common form of hereditary deafness in humans is caused by mutations in the GJB2 gene, which encodes the gap junction protein connexin 26. That regulates the transport of potassium and ...