The universal cell-cycle inhibitor p21 Cip1/WAF1 is phosphorylated ... as a result of its physical association with the oncogenic Akt protein. Subcellular mislocalization of checkpoint controllers ...

In amongst a clutch of discontinued phase 3 programmes in Roche's fourth-quarter results update was the news that it has stopped a study of AKT inhibitor ipatasertib as a treatment for first-line ...

Inflammasome activation and IL-1β secretion were measured in monocytes of patients with AATD, and following C3d stimulation in the presence or absence of CR3 or NLRP3 inhibitors. Results C3d acting ...

Finally, we review the chemical structures, indications, and research stages of various secretase inhibitors, emphasizing the promising development of secretase ... NCSTN can regulate the activity of ...

Janus kinase (JAK) inhibitors are a group of medications that can treat various types of arthritis, including rheumatoid arthritis (RA), cancer, dermatological conditions like atopic dermatitis and ...

The gap between preclinical promise and clinical outcomes underscores the need to investigate factors influencing the success or failure of targeted therapies. Dasatinib, an inhibitor of Abl and Src ...

Qualifications of elders and bishops; Christian citizenship; Paul's appeal for Onesimus. Put them in mind to be subject to principalities and powers, to obey magistrates, to be ready to every good ...

The NFL has announced its International Player Pathway (IPP) program Class of 2025 featuring 14 athletes representing 13 nations around the world, as the league continues to focus on creating more ...