The company’s commercial product portfolio includes Auvelity (dextromethorphan-bupropion), a N-methyl-D-aspartate receptor antagonist, sigma-1 receptor agonist, aminoketone, and CYP2D6 inhibitor ...

However, the intricate mechanisms governing these processes have remained elusive due to the presence of multiple functional domains within Munc13, each playing distinct roles in neurotransmitter ...

Magnesium supports many important functions in the body, including energy creation, blood sugar control, muscle and nerve ...

normally a glycine (G), is replaced with an aspartate (D)) — have proved resistant to classical drug-discovery paradigms, despite the best efforts of the world’s leading pharmaceutical ...

If you or someone you know has been diagnosed with Alzheimer's disease, you may feel scared, frustrated, and more. While there is no cure for Alzheimer's at this time, there are many ways to treat the ...

The directionality of channels is dictated by the electrochemical gradient. The authors reveal the structure and gating mechanisms of BRTNaC1, a myriapod ion channel sensitive to heat and acidity.

The enzyme’s key structural features gave the team a clear design goal: the active site contains a catalytic triad of serine, histidine, and aspartate residues that bind the substrate and form an ...