Most neuroscience research carried out up to date has primarily focused on neurons, the most renowned type of cell in the ...

Astrocytes play a crucial role in mediating surgery-induced anxiety in mice through modulating GABAergic signaling in the ...

We will further review astrocyte function and the impact on AD. Table 1. Example studies of astrocyte heterogenity in AD. As astrocyte isolation is challenging, the proportion of astrocytes obtained ...

We will begin by highlighting a subset of the many cellular functions of astrocytes, focusing specifically on those functions that have the most relevance to neurodegeneration (Figure 1).

Future directions might also include modalities to examine astrocyte function in vivo. In vivo imaging of astrocyte–astrocyte communication (e.g. calcium waves) has already been carried out in ...

This dissertation focuses on the glial protein GFAP and Alexander disease, a severe neurological disorder primarily affecting young children. Mutations in the GFAP gene disrupt astrocyte function, ...

Targeting glial Cxs, through Cx43 knockout (KO) or hemichannels (HCs) blockers, induces a beneficial effect, leading to a reduction in gliotransmitters release, neuronal damage, oxidative stress, and ...

A key research question is whether impairments in astrocyte mitochondrial function drive reactive astrogliosis associated with cognitive impairment. Logan and members of her lab are working to address ...