BRAF V600E mutations are common in different tumor types (more frequently in melanomas, colon and thyroid carcinomas). BRAF Alterations in Brain Tumors: Different Diagnostic Relevance of BRAF ...
Novartis' two-drug regimen of Tafinlar and Mekinist has been approved by the FDA as the first therapy for solid tumours that have a BRAF V600E mutation – regardless of where they occur in the body.
and a combination regimen for BRAF V600E-positive colorectal cancer with Pfizer’s Braftovi (encorafenib) and Eli Lilly’s Erbitux (cetuximab). It also covers Novartis’ Mekinist (trametinib ...