脂肪组织与中枢神经系统之间存在复杂的通信机制，以维持全身能量稳态。传统观点认为，脂肪组织通过分泌循环激素向大脑传递代谢状态信息，而大脑则通过交感神经输出调节脂肪细胞功能。背根神经节（DRG）的感觉神经元也被证实支配脂肪组织，但其生理重要性因缺乏特异性 ...

Researchers reveal that the loss of mucin-type O-glycosylation in the brain endothelial glycocalyx weakens the blood-brain ...

Feb. 11, 2025 — Scientists have developed an innovative method for growing brain tumors of individual patients in the laboratory that mimic the original structure and the molecular property of ...

TFE3 overexpression attenuates α-Syn toxicity in a mouse model of Parkinson's disease. TFE3 overexpression rescues autophagy defects of dop ...

As Rare Disease Day is commemorated on 28 February, experts discuss the barriers to gene therapy access for some rare ...

This recent study highlights the neuroprotective potential of TFE3, a transcription factor that plays a pivotal role in counteracting key pathological mechanisms associated with Parkinson's disease ...

但希望之光已然显现：研究者通过腺相关病毒（AAV）基因治疗，将衰老小鼠脑血管的糖萼厚度恢复83%，不仅逆转血管渗漏，更让20月龄老年鼠在迷宫测试中展现超越年轻组的空间记忆能力。这项颠覆性发现不仅重新定义了血脑屏障的防御机制，更为对抗阿尔茨海默病开辟了 ...

Voyager Therapeutics, Inc. (Nasdaq: VYGR), a biotechnology company dedicated to advancing neurogenetic medicines, today ...

Qure's stock rises on Huntington's therapy progress and strong gene therapy pipeline. Learn about QURE stock's cost-cutting ...

A study led by UMass Chan Medical School researchers has demonstrated that a gene therapy to correct a mutation that causes ...