The discovery of HIV coreceptors, such as CCR5 and CXCR4, has prompted a search for inhibitors against these receptors as an alternative therapy to HAART. Although new anti-HIV drugs that target ...

5B). MIP-1α specifically bound to CCR5-expressing cells and not to control cells expressing another chemokine receptor, CXCR4. The binding of radiolabeled MIP-1α to the CCR5-expressing cells was ...

库欣病（Cushing disease）是一种由ACTH型垂体瘤引起的全身代谢性疾病，其高皮质醇血症严重损害心血管和免疫系统功能，显著增加感染风险，并缩短 ...

1Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. 2Department of Surgery, Keio ...

There is currently little data on the polymorphisms in the CCR5 promoter in Chinese populations. A study on 96 HIV negative Chinese individuals in Taiwan indicates that only CCR5P1 and P4 ...

5. 异体 CAR33-NKT 细胞具有独特的骨髓归巢能力，由 CXCR4/CCR5 表达介导 在体内 PK/PD 研究中，通过 BLI 监测发现，Allo15CAR33-NKT/FG 细胞在 NSG 小鼠体内迅速扩增，具有较强的骨髓归巢能力，主要聚集在股骨、骨盆、肋骨和脊柱等部位。而传统 CAR33-T/FG 细胞虽也有扩增 ...

Experiments using cells that expresses both CXCR4 and CCR5, such as human peripheral blood mononuclear cells, rarely result in the selection of drug-resistant viruses that change coreceptor usage.

As a key inflammatory receptor family, the C-C chemokine receptor family is a remarkable participant in the cause of Alzheimer’s disease; of this family, CCR5 is the most widely studied. CCR5 is an ...

Within the context of vaginal or rectal transmission, HIV-1 must first cross a normally protective mucosal epithelium to reach the underlying dendritic cells, macrophages, and T cells which all ...