Computational analysis of the variations in the HIV-1 genome sequence that correlate with preferential binding to the CCR5 (C-C-motif receptor 5) or CXCR4 (C-X-C motif receptor 4) coreceptors in ...

5B). MIP-1α specifically bound to CCR5-expressing cells and not to control cells expressing another chemokine receptor, CXCR4. The binding of radiolabeled MIP-1α to the CCR5-expressing cells was ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

The discovery of HIV coreceptors, such as CCR5 and CXCR4, has prompted a search for inhibitors against these receptors as an alternative therapy to HAART. Although new anti-HIV drugs that target ...