I-DXd targets B7-H3, a protein overexpressed on the surface of a wide variety of cancer cells that bind to the CD28 family of receptors, which includes PD-1, targeted by MSD's widely used ...

在肿瘤治疗领域，嵌合抗原受体（CAR，Chimeric antigen receptor）-T（即 CAR-T）细胞疗法作为一种革命性的免疫治疗方法，已经在血液肿瘤治疗中取得了显著成效。过去几年，美国食品药品监督管理局（FDA，Food and ...

It is worth noting that in addition to TERT, the production of immune regulatory factors is also influenced by multiple issues. For example, Parish et al. observed that sustained CD28 expression ...

I-DXd targets B7-H3, a protein overexpressed on the surface of a wide variety of cancer cells that binds to the CD28 family of receptors, which includes PD-1, targeted by MSD's widely used ...

Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas. *Corresponding Author: Katayoun Rezvani, Department of Stem Cell ...

CTLA-4在活化的T和B淋巴细胞上表达。CTLA-4在结构上与T细胞共刺激蛋白CD28相似，并且两种分子都与B7家族成员B7-1（CD80）和B7-2（CD86）结合。配体结合后，CTLA-4负调节细胞介导的免疫反应。CTLA-4在诱导和维持免疫耐受、胸腺细胞发育和保护性免疫调节中发挥作用。

欢迎关注凯莱英药闻2024年10月18日，根据CDE官网显示，阿斯利康递交了Tremelimumab注射液的上市申请，该药物曾在海外已经获批与PD-L1抗体联用一线治疗肝细胞癌和非小细胞肺癌。本次申请中，公司也同时递交了度伐利尤单抗的上市申请，意味两 ...

Over the past three decades, laboratory and clinical research findings have shown that T cells are the primary mediators of psoriasis pathogenesis and that psoriasis can be treated by eliminating ...

College of Life Sciences, Key Laboratory fohr Cell and Gene Engineering of Zhejiang Province, Zhejiang University, Hangzhou, China Department of Genetic and Metabolic Disease, the Children’s Hospital, ...