1 Department of Pharmacy, The Affiliated Yixing Hospital of Jiangsu University, Yixing, China 2 Department of pharmacy, Jiangsu Province Hospital, Nanjing, China Immunotherapy has become a global ...

Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window HOUSTON -- Two-thirds of patients with PI3K-mutant brain metastases responded to the maximum tolerated dose (MTD ...

程序性死亡受体-1（PD-1）的基因于1992年由日本科学家Honjo在小鼠中分离、鉴定，在经历细胞死亡的T细胞杂交瘤中发现，因此得名。PD-1与CTLA-4、CD28和KIRs的结构具有相似性，人们因此猜测PD-1的配体可能是B7或MHC I家族成员。在2000年和2001年，Honjo和Freeman先后发现了PD ...

程序性死亡受体-1（PD-1）的基因于1992年由日本科学家Honjo在小鼠中分离、鉴定，在经历细胞死亡的T细胞杂交瘤中发现，因此得名。PD-1与CTLA-4、CD28和 ...

The YMNM cytoplasmic motif found in human CD28, which contains motifs for the binding of PI3K (YxxM) and GRB2/GADS (YxNx) is conserved in lungfish, sterlet, and spotted gar. In teleosts, the motif is ...