程序性死亡受体-1（PD-1）的基因于1992年由日本科学家Honjo在小鼠中分离、鉴定，在经历细胞死亡的T细胞杂交瘤中发现，因此得名。PD-1与CTLA-4、CD28和KIRs的结构具有相似性，人们因此猜测PD-1的配体可能是B7或MHC I家族成员。在2000年和2001年，Honjo和Freeman先后发现了PD ...

The YMNM cytoplasmic motif found in human CD28, which contains motifs for the binding of PI3K (YxxM) and GRB2/GADS (YxNx) is conserved in lungfish, sterlet, and spotted gar. In teleosts, the motif is ...

这一翻译控制通路可在T细胞活化后通过CD28-PI3K-mTORC1-eIF4F轴增强AMBRA1翻译，调节FAS和其他免疫相关基因的表达。 进一步，科研人员利用一系列蛋白互 ...

Immunotherapy for breast cancer is now being considered clinically, and more recently, the number of investigations aimed specifically at nano-biomaterials-assisted immunotherapy for breast cancer ...

Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu 30044, Taiwan, R.O.C Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei ...

Advanced prostate malignancies are a leading cause of cancer-related deaths in men, in large part due to our incomplete understanding of cellular drivers of disease progression. We investigate ...

T cell activation requires engagement of a cognate antigen by the T cell receptor (TCR) and the co-stimulatory signal of CD28. Both TCR and CD28 aggregate into clusters at the plasma membrane of ...

38 Nevertheless, studies using proteomic analysis have confirmed AKT phosphorylation in FL samples, which is indicative of PI3K pathway activation. 39,40,42,43 Additional evidence for the ...