但当 CD8 存在时，情况则相反，更强的 3D 结合亲和力会降低 TCR 对同源抗原（如 R4-MHC）的敏感性和特异性，却增加对非刺激抗原（如 L4-MHC）的敏感性。这表明 CD8 与 TCR-pMHC 结合在调节 TCR 特异性上存在复杂的协同效应。 考虑到 TCR 与 pMHC 在二维（2D）质膜上结合 ...

In the direct pathway of allorecognition, intact donor Major Histocompatibility Complex (MHC) molecules are recognised on the surface of donor cells. Conversely, donor MHC can be internalised and ...

Memorial Sloan Kettering Cancer Center researchers have found RNA neoantigen vaccines that generate long-lived, functional ...

目前，MS 的发病机制仍是医学界亟待解开的谜题。已知它涉及针对髓鞘抗原的自身免疫反应，其中辅助性 T 细胞 4（CD4 + T 细胞），尤其是 Th1 和 Th17 亚群，在推动疾病进展中 “扮演” 着重要角色。然而，细胞毒性 T 细胞 8（CD8 + T 细胞）在 MS 和实验性自身免疫性脑脊髓炎（Experimental Autoimmune ...

Recipient T cells recognize donor antigens via two distinct pathways: the direct pathway (intact donor MHC molecules displayed on donor antigen-presenting cells [APCs]) and the indirect pathway ...

CD8+ T cells play a crucial role in the control and resolution of viral infections and can adopt a wide range of phenotypes and effector functions depending on the inflammatory context and the ...

cDC1是一类高度特化的树突状细胞亚群，其核心功能在于通过交叉呈递（cross-presentation）将外源性抗原递送至MHC-I分子，激活CD8+T细胞，直接杀伤肿瘤细胞。其生物学特性包括： 通过细胞质和囊泡两条途径将抗原加工并装载至MHC-I，激活CD8+ T细胞，这一过程依赖SEC61 ...

Given the MHC-I and MHC-II associations with human SpA spectrum disorders ... Bulk RNAseq highlights the presence of clonal populations in both CD4+ and CD8+ conventional T-cell populations with the ...