Chronic fatigue syndrome creates conditions where pathogen-killing immune T cells become exhausted, according to a new ...

老规矩，奇点糕开头先问大家一个问题：在激活CD8+T细胞抗肿瘤免疫应答时，有哪些细胞会起到重要作用呢？回答树突状细胞（DCs）是肯定没问题的，它们的抗原呈递功能确实广为人知，但各位要记住了，从今天开始DCs可就不是问题唯一的“正解”了。因为在今天的《 ...

Chronic fatigue syndrome creates conditions where pathogen-killing immune T cells become exhausted, according to a new study.

“抗癌网红XX去世”这样的热搜，奇点糕近期看到过好几回了，加上最近又有朋友的朋友四十出头就确诊了急性白血病，不得不感叹一下生命的脆弱。但从传播学规律来说，抗癌网红们一开始会受到关注，往往是因为确诊时还算年轻，与传统认知有反差，那传统认知是什么？不就是 ...

Debilitating chronic fatigue syndrome creates conditions where a kind of immune cell that identifies and kills pathogens, ...

为了进一步探究衰老导致TRM分化受到抑制的分子机制，通过多因素基因筛选发现，在老年个体来源CD8+?T细胞中，E3泛素连接酶BFAR的高表达会抑制TRM细胞的产生；在机制方面，E3泛素连接酶BFAR可通过直接介导去泛素化酶USP39的泛素化并使其活化，进而促进USP39对JAK2的去泛素化，从而抑制了细胞因子诱导的JAK-STAT信号通路的激活，最终导致TRM的分化的降低及其介导的机体抗肿瘤免疫反 ...

伴随着衰老过程，人类患癌症风险上升。普遍认为，个体衰老进程导致DNA损伤和原癌基因激活，进而诱导细胞发生癌前病变。有研究提出，免疫衰老是衰老个体共有的生理现象。免疫衰老是伴随年龄增长出现的免疫系统的退行性改变，是导致个体“免疫力”下降进而诱发包括肿瘤 ...

A research team from the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences has revealed ...

“By screening candidate genes frequently gained in cancer, we identified expression of ubiquitin-like UBA1 as being the most negatively correlated with signatures related to effector CD8+ T-cells,” ...

In a study published in Nature Aging on Nov. 26, a research team from the Shanghai Institute of Nutrition and Health (SINH) ...