The current CF drug development landscape has expanded to include therapies that enhance CFTR function by either restoring wild-type CFTR protein expression or increasing (modulating) the function of ...

Researchers introduced functional porosomes into the plasma membrane of CFTR mutant cells to demonstrate that porosome reconstitution normalizes mucus secretion more than twice as effective than ...

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Upon secretion, they are unpacked into large disulfide-bond polymers, a process that requires an increased pH by bicarbonate transported via the cystic fibrosis transmembrane conductance regulator ...

Porosome Therapeutics, Inc. (Porosome Therapeutics) today announced the Orphan Drug Designation of its cystic fibrosis therapy by the Food and Drug Administration (FDA).

Leo's leadership is tested by the Kraang, challenging his calm demeanor. Nickelodeon revamps TMNT in 2012, successfully combining comedy and adventure. Leo's emotional struggles and family loyalty ...

Researchers are developing BI 3720931 to treat patients with cystic fibrosis, a genetic disease caused by certain variants in the CFTR gene. BI 3720931, which patients receive by inhaling, is a gene ...